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Identifier 000404263
Title Regulation of protein synthesis in the brain
Alternative Title Ρύθμιση της πρωτεϊνοσύνθεσης στον εγκέφαλο
Author Αμβροσιάδης, Θεόκλητος
Thesis advisor Καραγωγέως, Δ.
Γκόγκας, Χ.
Σιδηροπούλου, Κ.
Abstract mRNA translation is a fundamental cellular function that is tightly regulated by intra-cellular signaling pathways. Translation initiation is a crucial step of this process in eukaryotic cells and is, thus, under the most extensive regulation. Dysregulation of protein synthesis in the brain has been implicated in various neuropsychiatric disor-ders, among which autism spectrum disorder (ASD) is the focus of the present study. Mutations of the contactin-associated protein-like 2 (CNTNAP2) gene are associated with development of ASD and related disorders in humans and lead to ASD-like phe-notypes in mice. However, a molecular mechanism to explain these observations is lacking. Here we show that knockout of CNTNAP2 in mice leads to excessive mRNA translation, potentially mediated by the hyperactivation of the mammalian target of rapamycin complex 1 (mTORC1) that we observed. In the second part of this thesis, we make use of a previously described technique to isolate and study adult neural stem cells (NSCs) in culture.
Language English
Subject Autism
Αυτισμός
Νευροψυχιατρικές διαταραχές
Issue date 2016-12-13
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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