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Identifier

000379503

Title

Ανάπτυξη της φασματομετρίας μάζας υπερηχητικής εκνέφωσης : Σύγκριση με τον ηλεκτροψεκασμό

Alternative Title

Development of sonic spray mass spectrometry-comparison with electrospray

Author

Αντωνάκης, Μάνος Μαμ

Thesis advisor

Περγαντής, Σπύρος

Reviewer

Βασιλικογιαννάκης, Γεώργιος
Σπύρος, Απόστολος

Abstract

ABSTRACT Mass spectrometry has been established as a predominant technique in chemical analysis due to its high sensitivity, selectivity and speed. To generate ions mass spectrometers use a number of different sources appropriate for different categories of molecules.Some operate under high vacuum i.e electron ionization, while others operate under atmospheric pressure i.e electrospray ionization. Thus, molecules sensitive to decomposition under electron ionization conditions can be analyzed with electrospray. A number of alternative spraying sources i.e. thermosray, ionspray, atmospheric pressure chemical ionization, have been proposed for generating ions from sensitive biomolecules and inorganic compounds. Recently, the generation of ions from solution without applying heat, potential or excited gas has been proposed by Hirabayashi.The sonic spray ionization source, as named, generates ions from solution being sprayed from a coaxial inert gas with speed approximating that of sound i.e sonic speed.The major advantages of sonic spray source are the absence of thermal, electrochemical interference, generation of ions under soft conditions and simplicity of usage. In 2011, Eberlin’s research group, proposed the combination of sonic spray ionization and Venturi effect for self-aspiration of solution and ionization of analyte.Thus, no voltage is needed nor pump-syringe system for introducing solution.This technique was named Venturi Easy Ambient Sonic Spray Ionization (V-EASI). The objective of the present study is 1) utilize pneumatic nebulizers, used in atomic techniques, to create a sonic spray source with self-aspirating introduction of solution sample i.e V-EASI, for analysis of molecules 2) optimization of parameters affecting source sensitivity and 3) comparison of V-EASI source with electrospray source and application of the V-EASI source to chemical analysis of sensitive compounds

Language

Greek

Subject

Venturi effect

electrospray

ion source

mass spectrometry

sonic spray

ηλεκτροψεκασμός

πηγή ιόντων

υπερηχητική εκνέφωση

φαινόμενο Venturi