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Home    Συμπεριφορικές δράσεις του mGLUR2/3 αγωνιστή LY379268 σε πειραματικά πρότυπα άγχους και ιδεοψυχαναγκαστικής διαταραχής  

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Identifier 000369900
Title Συμπεριφορικές δράσεις του mGLUR2/3 αγωνιστή LY379268 σε πειραματικά πρότυπα άγχους και ιδεοψυχαναγκαστικής διαταραχής
Alternative Title Behavioural effects of MGLUR2/3 agonist LY379268 in animal models of anxiety and obsessive compulsive disorder
Author Γρίβας, Βασίλειος
Thesis advisor Πιτσίκας, Νικόλαος
Abstract LY379268 is agonist of group II metabolotropic receptors of glutamate. These receptors are presynaptic autoreceptors and decrease glutamate neurotransmission.This decrease occurs in cases that glutamate neurotransmission is overactivated, especially in pathological conditions. Aim of present stydy was the effect of LY379268 in animal models of anxiety and obsessive compulsive disorder.Results in animal model of anxiety indicated an anxiogenic effect of 3 mg/kg dose. As it concerns the doses (0.3 and 1 mg/kg), we did not reveal any anxiolytic effect of LY379268. Additionally, as far as it concerns animal model of obsessive compulsive disorder it has been established from studies that mCPP exarcabates grooming behaviour which resembles with human οbsessive compulsive disorder symptoms. LY379268 decreased significantly grooming behaviour and this finding renders it as a possible therapeutic tool in this specific disorder
Language Greek
Subject Anxiety
MGLUR2/3 agonist LY379268
Obsessive compulsive disorder
Phychiatry
Άγχος
Ιδεοψυχαναγκαστική διαταραχή
Issue date 2010-07-20
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Notes Πρόγραμμα μεταπτυχιακών σπουδών" Νευροεπιστήμες "
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