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Home    Ο ρόλος της ιντερλευκίνης (IL)33 και του υποδοχέα ST2 στην στεφανιαία νόσο/Ισχαιμική μυοκαρδιοπάθεια.Προσέγγιση μέσω πληθυσμιακής γενετικής.  

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Identifier 000376527
Title Ο ρόλος της ιντερλευκίνης (IL)33 και του υποδοχέα ST2 στην στεφανιαία νόσο/Ισχαιμική μυοκαρδιοπάθεια.Προσέγγιση μέσω πληθυσμιακής γενετικής.
Alternative Title Genetic variability of the distal promoter of the ST2 gene is associated with angiographic severity of coronary artery disease
Author Τσαπάκη, Υπαπαντή
Thesis advisor Σπαντίδος, Δημήτριος
Reviewer Γουλιέλμος, Γ.
Κοχιαδάκης, Γ.
Abstract Genetic polymorphy of the distal promoter region of the ST2 gene influences transcriptional activity and susceptibility to atopic dermatitis and asthma. Based on the inflammatory background of atherosclerosis we hypothesized that ST2 distal promoter genetic polymorphy could also affect susceptibility to coronary artery disease (CAD). To test our hypothesis we performed direct sequencing of a 825 bp locus of the distal promoter ‐with previously reported significant polymorphy‐ in 63 angiographically diagnosed CAD patients and 63 age and sex matched controls with negative coronary angiography. We identified 13 polymorphisms spanning this region two of which (‐27307 T/A and ‐27614 C/A) had allele frequencies grater than 0.05. We further genotyped 111 subjects ‐applying allele specific real‐time PCR‐ for the ‐27307 T/A and 27614 C/A polymorphisms increasing our sample number to 129 CAD patients and 108 age and sex matched controls. We identified no phenotype‐genotype interactions between cases and controls. However, among case subjects severity of CAD expressed as mean number of diseased vessels was greater in ‐27307 A allele carriers and either allele carriers (‐27614 A or ‐27307 A) than non carriers (2.56±0.73 vs. 1.83±0.84, adjusted p=0.027; 2.47±0.74 vs. 1.8±0.83, adjusted p=0.023). Additionally either allele carriers (‐27614 A or ‐27307 A) were significantly more common in the multi‐vessel disease group (n=54) than in the single‐vessel disease group (n=75). In conclusion, we reported two new polymorphisms in the distal promoter region of the ST2 gene that possibly influence susceptibility to sever CAD. The functional impact of these polymorphisms remains to be determined.
Language Greek
Subject Atherosclerosis
Coronary disease
Inflammation
Interleukin 33
Ischemic cardiomyopathy
Polymorphisms
Promoter ST2
Αθηροσκλήρυνση
Ιντερλευκίνη 3
Ισχαιμική μυοκαρδιοπάθεια
Πληθυσμιακή γενετική
Πολυμορφισμοί
Στεφανιαία νόσος
Υποδοχέας ST2
Φλεγμονή
Issue date 2011-12-15
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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