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Identifier 000351251
Title Απομόνωση και χαρακτηρισμός πρωτεϊνικών συμπλοκών που συμμετέχουν στις διαχρωμοσωμικές αλληλεπιδράσεις γενετικών τόπων κυτοκινών
Alternative Title Isolation and characterisation of protein complexes that mediate interchromosomal interactions of cytokine genetic loci
Author Τζέρπος, Πέτρος
Thesis advisor Παπαματθαιάκης, Ιωσήφ
Abstract Genome organization and high order chromatin structure are key features in the highly compartmentalized and dynamic environment of the eukaryotic nucleus. Recent studies have indicated that gene positioning and chromosomal interactions (cis & trans) in the nucleus may play an important role in gene expression. Although regulation of gene expression by cis regulatory elements (promoters, enhancers, silencers, locus control regions etc) is well established, it was not until recently shown that trans interactions between different chromosomes can play a role in transcriptional regulation. Because mechanistic details of how these interactions are formed are still lacking, the main aim of this thesis was to contribute to the elucidation of the molecular mechanisms of trans interactions and to establish a role for specific protein complexes in the generation and maintenance of interchromosomal interactions in mouse T cells. To this end, we applied DNase I footprinting assay to characterize the protein factors that bind to regulatory regions to the TH2 locus and potentially regulate interchromosomal interactions in CD4+ T helper cells.
Physical description
32 σ. : εικ. ; 30 εκ.
Language Greek
Subject Cytokines
Κυτοκίνες
Issue date 2009-11-20
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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