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Identifier

uch.med.phd//1994DIS0040

Title

Ρύθμιση της έκφρασης του ιού του AIDS του ανθρώπου HIV-1

Alternative Title

Regulation of the Human immunodeficiency virus (HIV-1) expression

Creator

Zoumpourlis, Vassilis K

Abstract

The regulatory sequences contained in the LTR of HIV-1 were studied. For this purpose we employed biological response modifies(insulin, epidermal growth factor), hormones(hydrocortisone, dexamethasone) and anti-tumor drugs(CIS-platin, carboplatin, doxonbium, daunomium, mitonogene and hexamethylene-biacetamide) on rat and human fibroblasts expressing the reporter gene chloramphenicol acetyl tranferase(CAT) from th HIV-1 LTR. These compounds were found to be powerful inducers of HIV-1 expression in the oncoproteins like the jun/tos (AP-1) which are overexpressed in human cancers were also studied to examine whether they interest with regulatory sequences of HIV-1 LTR. Proteins with AP-1 like activity were found in three HIV-1 LTR sequences.

Issue date

1994-00-01

Date available

1997-06-6

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

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