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Identifier

000304753

Title

Σχεδιασμός και σύνθεση μεθυλο-αζα-μακροκυκλικών δεικτών κουμαρινικού τύπου για τον φθορισμομετρικό προσδιορισμό ιόντων βαρέων μετάλλων

Alternative Title

Synthesis of methyl-aza-macrocyclic-sunstituted coumarins, designed as indicators for the fluorometric determination of heavy metal ion concentrations

Author

Βουτσαδάκη, Στυλιανή Μάρκου

Thesis advisor

Κατερινόπουλος, Χαράλαμπος

Abstract

In the present work, four methyl-aza-macrocyclic ion indicators, containong substitutd coumarins as chromophores, were synthesized. In the first two structures the 1-aza-15-crown moiety is incorporated as ionophore, while the other two contain the 1,4,8,11-Tetraazacyclotetradecane (cyclam) moiety. The latter products were isolated as mixtures of mono- and di-substituted cyclam, with the di-substituted congener in excess, given that the compounds could not be separated by conventional chromatographic methods. Preliminary luorescence studies were carried out with the 1-aza-15-crown-5-type indicators and standard solutions of Zn²⁺ and Cd²⁺. Both compounds responded to increases of ion concetrations exhibiting changes in their fluorescence spectra. The dissociation constants of one indicator were calculated as K_d=8.7 μM for Zn²⁺ and K_d=16nM for Cd²⁺ ions. The above values indicate that the above mentioned indicators could be used as ion probes for the selective detection of Zn²⁺ and Cd²⁺ ions.

Language

Greek

Subject

1,4,8,11- tetraazacyclotetradecane

1-aza-15-crown-5

Cd2+

Fluorocent indicators

Zn2+

coumarins

cyclam

fluoroscene

κουμαρίνες