Your browser does not support JavaScript!

Home    Δημιουργία διαγονιδιακού ποντικού με σκοπό να αποτελέσει μοντέλο για την ασθένεια alzheimer  

Results - Details

Add to Basket
[Add to Basket]
Identifier uch.biology.msc//1998soutoglou
Title Δημιουργία διαγονιδιακού ποντικού με σκοπό να αποτελέσει μοντέλο για την ασθένεια alzheimer
Author Σουτόγλου, Ευανθία
Thesis advisor Παπαματθαιάκης, Ιωσήφ
Abstract The Alzheimer disease is a neurodegenerative disease, the main neuropathological characteristics of which are the extended accumulation of extracellular amyloid plaques (senile plaques), the loss of nerve cells and cerebral inflammations in the neocortex, the hippocampus and the amygdaloid nucleus. Four genes have been genetically linked with the familial cases of the disease. The first is the gene for Amyloid Precursor Protein (APP) from which the Αβ peptide is derived, which is the main component of amyloid plaques. Two other genes, PS1 and PS2, which are homologous to each other, seem to play an important role in the pathogenesis, increasing the quantity of the secreted Αβ peptide. The last gene, is the gene coding for APOE, a protein that participates in cholesterol metabolism and is localized in senile plaques. The main aim of the present study is the development of a transgenic mouse containing in its genome and expressing the human APP protein, to use as a model for the Alzheimer disease, to both, that is, exhibit the pathological characteristics and the behavior of Alzheimer patients (memory loss, learning impairment). A construct containing a mutated form of APP (V717F, K670N, M671L) under the control of human PDGF promoter was used to generate transgenic animals. Three founders bearing different copy number of the transgene were selected and bread to obtain transgenic lines. Preliminary analysis of two of these lines, showed high level expression of APP mRNA.
Language Greek
Issue date 1998-11-19
Date available 1998-10-21
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
Views 226

Digital Documents
No preview available

Download document
View document
Views : 2