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Identifier

000333616

Title

Κοινωνικοποίηση των γονιδίων : γονιδιακή σειρά, γονιδιακή αποσιώπηση και εξέλιξη των βακτηρίων Salmonella typhimurium LT2 και Escherichia coli K-12

Author

Τραχανά, Καλλιόπη

Thesis advisor

Ηλιόπουλος, Ιωάννης

Reviewer

Σαββάκης, Χ.
Ηλιόπουλος, Ι.

Abstract

Genes of conserved order (linked genes) tend to evolve slower than those genes whose order is not conserved. This study confirms that proteins encoded by linked genes in two closely related bacterial species, namely Escherichia coli K12 and Salmonella typhimurium LT2, evolve more slowly when compared with proteins encoded by genes that are not linked as assessed by protein sequence similarity studies. Moreover, essential genes tend to retain their gene order, whereas genes repressed by H-NS (Ηistone-like Νucleoid Structuring) protein belong mainly to the group of not linked genes or to the group of genes that do not have any homolog between the two genomes. Using information from functional and comparative genomics, we propose the existence of a strong association between gene order, GC content and gene silencing in model bacterial species. Finally, by analyzing the Gene Ontology Annotations for both organisms, it has been revealed that proteins which participate in metabolic pathways tend to be encoded by linked genes, in contrast to regulatory proteins.

Language

Greek

Subject

Evolution, Molecular

Gene Expression Regulation

H-NS

gene ontology

γονιδιακή οντολογία

Issue date

2008-12-04

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses