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Home Ο ρόλος των λιπαρών οξέων του υποδόριου λίπους και του γαστρικού βλενογόννου στους αμυντικούς μηχανισμούς του βλενογόννου στομάχου

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Identifier

000363242

Title

Ο ρόλος των λιπαρών οξέων του υποδόριου λίπους και του γαστρικού βλενογόννου στους αμυντικούς μηχανισμούς του βλενογόννου στομάχου

Alternative Title

The role of fatty acids of the adipose tissue and the gastric mucosa in the defence of the gastric mucosa

Author

Πάγκαλος, Βασίλειος Α

Thesis advisor

Κουρούμαλης, Ηλίας

Reviewer

Καφάτος, Αντώνης
Μουζάς, Ιωάννης

Abstract

Background Both in vitro and epidemiological studies indicate that dietary polyunsaturated fatty acids may play a protective role against peptic ulcer in humans. Adipose tissue fatty acid composition is thought to reflect dietary fatty acid intake. The aim of the present study is to investigate adipose and gastric mucosa fatty acid levels in relation to gastric ulceration status. Methods Fifty two adult outpatients undergoing upper gastrointestinal tract endoscopy participated in the study. Adipose tissue samples were taken from the abdomen and buttock during the endoscopy procedure and samples from gastric tissue were taken from a subsample of 30 subjects. The presence of Helicobacter pylori was determined using the CLO test. Capillary gas chromatography was used for the extraction of adipose tissue and gastric mucosa lipids. Results The monounsaturated fatty acids (MUFAs) C18:1n‐12c, C16:1n‐5, C16:4n‐1 and the polyunsaturated fatty acids (PUFAs) C16:3n‐4, C20:3n‐3, C20:4n‐6, C21:5n‐3 and C18:2n‐ 9c,12t of the gastric mucosa were present in higher proportions in ulcer negative patients. In addition, higher average levels of eicosapentaenoic acid (EPA) C20:5n‐3 and docosahexaenoic acid (DHA) C22:6n‐3 were detected in abdominal and buttock samples in CLO negative controls, compared to CLO positive controls. Conclusions Certain MUFAs and PUFAs of the gastric mucosa appear to be present in higher proportions in ulcer negative patients. The higher average levels of EPA and DHA in abdominal and buttock adipose tissue in CLO negative controls could be an indicator that dietary FAs inhibit Helicobacter pylori growth.

Language

Greek

Subject

Adipose tissue

Fatty acids

Gastric mucosa

Helicobacter pylori

Peptic Ulcer

Γαστρικό έλκος

Γαστροδωδεκαδακτυλικό έλκος

Γστρικός βλενογόνννος

Ελικοβακτηρίδιο του πυλωρού