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Identifier |
000401033 |
Title |
Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους |
Alternative Title |
Adiponectin levels as a biological marker in immunologic and metabolic alterations in tumors |
Author
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Μιχαλάκης, Κωστής Γ.
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Thesis advisor
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Μαργιωρής, Ανδρέας
Γραβάνης, Αχιλλέας
Βενυχάκη, Μαρία
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Select a value
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Καστανάς, Ηλίας
Τσατσάνης, Χρήστος
Αγγελάκη, Σοφία
Καμπά, Μαρία
|
Abstract |
AIM: Adiponectin, an adipose tissue derived hormone with insulin-sensitizing
effects, has been inversely associated to several hormonally-dependent
malignancies. Prostate cancer is associated with low levels of adiponectin
which have been proposed as an independent risk factor for this malignancy.
Aim of the current study was to examine whether hypoadiponectinemia in
prostate is associated with to insulin resistance.
Experimental design: Plasma samples and covariate data in the context of
a case-control study of 300 Greek men were evaluated including 75 prostate
cancer patients, 75 patients with benign prostatic hyperplasia (BPH), and 150
age-matched healthy controls.
Results: Prostate cancer patients had significantly lower plasma adiponectin
levels compared to the other two groups i.e. BPH patients and healthy
controls (7.4±5ng/ml versus 11.5±6.4ng/ml and 12.8±8ng/ml, respectively).
On the other hand, no statistically significant differences were found between
prostate cancer patients and the other two groups for both HOMA-IR and
QUICKI (p-value= 0.551). As expected, in all three groups, the levels of
adiponectin correlated negatively with HOMA-IR (rho=-0.214, p-value=0.006),
QUICKI (rho=0.214, p-value=0.006) and insulin levels (rho=0.942, pvalue<0.001).
Conclusion: In spite to what would have been expected from the relevant
literature, our data suggest that the hypoadiponectinemia in prostatic cancer
does not appear to be associated to insulin resistance.
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Language |
Greek |
Subject |
Homa-quicki |
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Insulin resistance |
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Prostate cancer- |
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Ινσουλινοαντοχή |
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Καρκίνος προστάτη |
Issue date |
2016-03-17 |
Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
|
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Type of Work--Doctoral theses
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Views |
284 |