Your browser does not support JavaScript!

Home    Μελέτη της ενζυμικά καταλυόμενης στερεοεκλεκτικής μετατροπής πρωτοταγών αρωματικών αμινών σε αμίδια με τη φερουλουλο εστεράση απο humicola insolens  

Results - Details

Add to Basket
[Add to Basket]
Identifier uch.chemistry.msc//2005ximerakis
Title Μελέτη της ενζυμικά καταλυόμενης στερεοεκλεκτικής μετατροπής πρωτοταγών αρωματικών αμινών σε αμίδια με τη φερουλουλο εστεράση απο humicola insolens
Alternative Title Study on enzymatic stereoselective tranformation of primary aromatic amines to amides catalyzed by feroulic acid esterase from humicola insolens
Author Ξημεράκης, Δημήτρης
Abstract In this work, examined the enzymatic acylation of primary aromatic amines to amides, by feroulic acid esterase from Humicola Insolens. Initially it was demonstrated, that this enzyme catalyses the acylation of phenylethylamine with high enantioselectivity. In summary, our preliminary results have shown that feruloyl esterase from Humicola Insolens, can successively catalyse the stereoselective acylation of primary amines that bear no structural similarity to the natural substrates of this enzyme. These reactions proceed good enantioselectivity analogous to that of lipases. In all enzymatic reactions with triethylamine, the enzyme showed higher values of enantioselectivity. In polar solvents the enzyme showed higher values of enantioselectivity. At the acylation reaction the enzyme showed R-enantiopreference. FAE didnt hydrolase amides of the corresponding amines, so it has not a protease activity. The optimum temperature that was achieved during the enzymatic reactions was at 40oC. The best acyl donor was isopropyl acetate.
Language Greek
Issue date 2005
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
Views 206

Digital Documents
No preview available

Download document
View document
Views : 9