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Identifier

000398119

Title

Η πρωτεϊνη Smyd3 δρα ως μεταγραφικός ενισχυτής γονιδίων που προάγουν την καρκινογένεση του ήπατος και του παχέως εντέρου

Alternative Title

Smyd3 is a transcriptional potentiator of multiple cancer promoting genes and required for liver and colon cancer development

Author

Σαρρής, Μιχάλης

Thesis advisor

Ταλιανίδης, Ιωάννης

Reviewer

Γουλιέλμος, Γ.
Μπούμπας, Δ.
Μαυροθαλασσίτης, Γ.
Καρδάσης, Δ.
Χαλεπάκης, Γ.
Σπηλιανάκης, Χ.

Abstract

Smyd3 is a protein methyltransferase implicated in cancer development. Here we show that Smyd3 expression in mice is required for chemically induced liver and colon cancer formation. In these organs Smyd3 functions in the nucleus stimulating the transcription of several key regulators involved in cell proliferation, epithelial-mesenchymal transition, JAK/Stat3 oncogenic pathway, as well as of the c-myc and β-catenin oncogenes. Smyd3 interacts with H3K4Me3-modified histone tails, which facilitates its recruitment to the core promoter regions of most active genes. Smyd3 binding density on target genes positively correlates with increased RNA Polymerase-II density and transcriptional outputs. Despite its widespread distribution, the transcription potentiating function of Smyd3 is restricted to a particular set of genes whose expression is induced specifically during carcinogenesis.

Language

Greek

Subject

Colorectal carcinoma

Hepatocellular carcinoma

Histone methylase

Μεθύλαση ιστόνων

Issue date

2016-03-24

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses