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Home    Μεταβολές στα επίπεδα των VEGF, bFGF, TGF-β1, ET-1 και sKL, στο πλάσμα της εγκύου κατά τη διάρκεια της φυσιολογικής κύησης, της υπερτασικής κύησης και της διαβητικής κύησης  

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Identifier 000346945
Title Μεταβολές στα επίπεδα των VEGF, bFGF, TGF-β1, ET-1 και sKL, στο πλάσμα της εγκύου κατά τη διάρκεια της φυσιολογικής κύησης, της υπερτασικής κύησης και της διαβητικής κύησης
Alternative Title Changes in maternal plasma levels of VEGF, bFGF, TGF-β1, ET-1 and sKL during uncomplicated prgnancy, hypertensive pregnancy and gestational diabetes
Author Λυγνός, Μενέλαος Κ.
Thesis advisor Κουμαντάκης, Ευγένιος
Reviewer Ηλιόπουλος, Γεώργιος
Ματαλλιωτάκης, Ιωάννης
Abstract Background: Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), Transforming Growth Factor-beta1 (TGF-β1), Endothelin-1 (ET-1) and soluble c-kit ligand (sKL) are cytokines involved in embryogenesis. Materials and Methods: Maternal plasma cytokines were measured with ELISA during the three trimesters of gestation and on the day of delivery in 93 pregnant women and 18 age-matched non-pregnant control women. Results: The VEGF and bFGF levels increased during the first trimester and declined thereafter, but they remained above the controls’ values until delivery. The TGF-β1 levels increased during the first trimester and remained unchanged thereafter. On the contrary, the ET-1 levels decreased and remained low until delivery. VEGF, bFGF, TGF-β1 and ET-1 were increased in hyperstesive pregnancy. Except for ET-1, these cytokines were also increased in gestational diabetes. No changes in plasma sKL were documented. Conclusion: All the aforementioned cytokines play a role in uncomplicated pregnancy, whereas hypertensive pregnancy is causatively related with increased ET-1.
Physical description 99 σ. : πιν. ; 30 εκ.
Language Greek
Subject Cytokines
Pregnancy
Issue date 2007-07-26
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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