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Identifier uch.med.phd//1996DIS0085
Title Αλληλεπίδραση των ογκογονιδίων RAS με παπιλλομα-ιους και ερπητο-ιούς σε γυναικολογικές νεοπλασίες
Alternative Title Co-operation of RAS oncogenes with human papilloma-virus and herpes- viruses in gynecological neoplasms
Creator Koffa, Maria D
Abstract In the present study activation of RAS ongogenes as well as detection of HPV, CMV, HSV and EBV viruses were performed in gynaecological lesions using the polymerase chain reaction(PCR).Interactions of activating mutation with viral infections were also examined. It was found that K-RAS ongogene activation by codon 12 point mutations is an early event in the cercinogenesis of the cervix. Mutations were also found in the other types of maliglancies examined but at lower frequency. Detection of HPV,CMV and HSV was statistically associated with risk for cervical cancer. The simultaneously presence of RAS mutation and HPV was associated with frequent type was HPV 18. CVM and HSV may act as surrogate markers of HPV, or they play a separate etiological relo in cervical cancer.
Issue date 1996-08-01
Date available 1997-06-6
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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