E-Locus - Ιδρυματικό Καταθετήριο Πανεπιστημίου Κρήτης - Development of small molecule libraries for inhibition of ALOX15 enzyme

Αρχική Development of small molecule libraries for inhibition of ALOX15 enzyme

Αποτελέσματα - Λεπτομέρειες

[Προσθήκη στο καλάθι]

Τίτλος

Development of small molecule libraries for inhibition of ALOX15 enzyme

Συγγραφέας

Πολατίδου, Κατερίνα

Σύμβουλος διατριβής

Ελευθεριάδης Νικόλαος

Περίληψη

In this thesis libraries of small molecule for inhibition of 15-lipoxygenase type 1, were designed. ALOX15 or 15-lipoxygenase type 1 enzyme, is implicated in many serious diseases such as anaphylactic diseases, asthma, COPD, diabetes, neurodegenerative diseases, certain types of cancer and many others due to the production of pro- and anti-inflammatory metabolites. Because, the existing potent 15-lipoxygenase-1 inhibitors have undesirable properties, the aim of this thesis was to find new scaffolds that possess good inhibitory potency. In order to achieve that, we designed a library of compounds synthesized by medicinal chemistry groups and organic chemistry groups that synthesize natural products. Also, a library of the known inhibitors of ALOX15, with known activities was developed and used as a control for our experiments. Then, docking studies were conducted using the rabbit ortholog model of 15-lipoxygenase-1 (PDB-ID; 2P0M) to filter through these compounds and propose the best ones to continue with in vitro inhibition studies.

Γλώσσα

Αγγλικά

Ημερομηνία έκδοσης

2022-11-24

Συλλογή

Σχολή/Τμήμα--Σχολή Θετικών και Τεχνολογικών Επιστημών--Τμήμα Χημείας--Πτυχιακές εργασίες

Τύπος Εργασίας--Πτυχιακές εργασίες

Εμφανίσεις

288

Ψηφιακά τεκμήρια
	Κατέβασμα Εγγράφου Προβολή Εγγράφου Εμφανίσεις : 16