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Home    Κυττοαρχιτεκτονική οργάνωση της οπτικής καλύπτρας πτηνού βάση της έκφρασης της συνθάσης του μονοξειδίου του αζώτου κατά την ανάπτυξη και μετά τη διατομή του οπτικού νεύρου  

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Identifier uch.biology.msc//1998panagis
Title Κυττοαρχιτεκτονική οργάνωση της οπτικής καλύπτρας πτηνού βάση της έκφρασης της συνθάσης του μονοξειδίου του αζώτου κατά την ανάπτυξη και μετά τη διατομή του οπτικού νεύρου
Author Παναγής, Λάμπρος
Thesis advisor Δερμών, Κατερίνα
Abstract This study aimed to define the plasticity induced changes to the cytoarchitectonic organisation of the primary visual areas following monocular deprivation, to developing birds. Specifically, the result of early axotomy of the optic nerve on the expression of Nitric Oxide Synthase (NOS) by the cells of the avian optic tectum was studied. This agent (NO) has been the object of intensive research in the plasticity field since its expression has been shown to be subject to modulation as a result of trauma to the nervous system. The localisation of NOS was performed using the NADPH-diaphorase histochemical process. The evaluation of the results was performed by stereological analysis of the sectioned tissue, using the optical disector method. Following the axotomy of the optic nerve, an increase of the number of NOS expressing neurons was detected at the visually deprived tectum. The increase appears first at the dorso caudal part of the tectum and proceeds towards the rostro ventral. An increase in the number of positive cells, having the opposite direction, appears also to the side ipsilateral to the axotomy. The morphological analysis of the NOS positive cells further supports the above stated. These results suggest a significant role for NO in the shaping of the normal cytoarchitecture of the avian optic tectum. Even more significant is its role to the reorganisation, of the mono- and polysynaptic paths, that takes place during placticity procedures. These procedures aim in the replacement of the visual abilities of the organism as well as the utilisation of the sensory deprived tectum.
Language Greek
Issue date 1998-11-19
Date available 1999-07-16
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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