E-Locus - Institutional Repository of the University of Crete - Υπολογιστική ιεράρχηση γονιδιακών λιστών διαφορικής έκφρασης με ανάλυση ρυθμιστικών και λειτουργικών δικτύων

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Identifier

000403583

Title

Υπολογιστική ιεράρχηση γονιδιακών λιστών διαφορικής έκφρασης με ανάλυση ρυθμιστικών και λειτουργικών δικτύων

Alternative Title

Computational prioritization of differential gene expression lists via analysis of regulatory and functional networks

Author

Παπαδάκης, Αντώνιος Λ.

Thesis advisor

Νικολάου, Χριστόφορος

Reviewer

Ηλιόπουλος, Ιωάννης
Τζαμαρίας, Δημήτριος

Abstract

High-throughput technologies have generated a huge amount of data concerning the molecular interactions that transpire inside the cells. The prioritization of the candidate genes connected to diseases which have been derived from this data constitutes a fundamental challenge for the biomedical sciences, facilitating the development of new diagnostic methods and treatments. A considerable subset of the existing techniques utilizes biological networks, regulatory or proteinprotein- protein interaction ones, for gene prioritization, based on the notion that the products of genes that interact heavily in a network are more likely to associate with similar diseases. However, the noisy and incomplete nature of PPI(Protein-Protein Interactions) data remains an important challenge for these applications. The aim of this thesis is a genome-wide candidate gene prioritization using suitable computational methods. More specifically, eigenvalue algorithms are applied in order to effectively utilize the existing regulatory and functional PPI data for the extraction of the most important genes from differential expression lists derived from high-throughput experiments so that they can be applied in future experimental applications.

Language

Greek

Subject

Biological network

Differential expression

Gene prioritization

PageRank

Βιολογικά δίκτυα

Γονιδιακή ιεράρχηση

Διαφορική έκφραση

Issue date

2016-11-18