|
|
| Identifier |
000398613 |
| Title |
Σωματομετρικές απεικονιστικές και βιοχημικές μεταβολές σε νοσογόνα παχύσαρκους ασθενείς πριν και μετά την απώλεια βάρους με επεμβατικές μεθόδους |
| Alternative Title |
Computed tomography-based assessment of abdominal adiposity changes and their impact on metabolic alterations following bariatric surgery |
|
Author
|
Γαλανάκης, Χρήστος Γ.
|
|
Thesis advisor
|
Μελισσάς, Ιωάννης
Παπαβασιλείου, Ευστάθιος
De Bree Eelco
|
|
Reviewer
|
Λιονής, Χρήστος
Καραντάνας, Απόστολος
Γανωτάκης, Εμμανουήλ
Καμπά, Μαρία Ελένη
|
| Abstract |
The surgical treatment of morbid obesity with laparoscopic sleeve gastrectomy (LSG)
and laparoscopic adjustable gastric band (LAGB) is effective in terms of improving
the consequences of the disease.
The aim of this study was to evaluate the effects of surgically-induced weight loss on
the abdominal adipose tissue depots and the metabolic profile in morbidly obese
(MO) patients
The study was performed with a semi-automated quantification of adipose tissue
compartments on single-slice abdominal CT series before surgery, 6 months and 12
months after bariatric surgery. Thirty eight MO patients with mean age of 35.7±10.1
years and mean body mass index (BMI) of 43.6±6.5 kg/m2 were studied (20 patients
underwent gastric banding and 18 patients underwent sleeve gastrectomy).
Anthropometric measurements, metabolic and inflammatory parameters were
analyzed in each patient.
Markedly decreased levels of total abdominal adipose tissue (TAbAT), abdominal
subcutaneous adipose tissue (AbSAT) and visceral adipose tissue (VAT) at 6 months
and 12 months were noted in comparison to the preoperative values. The total %
reduction of VAT was significant higher in comparison to the total % reduction of
AbSAT at 12 months after bariatric surgery (p<0.01) with the mean ratio of
AbSAT/VAT to increase from 4.1±1.7 preoperatively to 6.2±3.1 at 12 months
postoperatively (p<0.001). In addition, high-sensitivity C-reactive protein (hsCRP)
decreased significantly with weight loss after bariatric surgery and the total abdominal
lipid loss was related to the decrease in hsCRP.
Significant changes in abdominal lipid deposition occurred in MO patients 6 and 12
months after bariatric surgery. The changes were significantly, correlated with the
magnitude of BMI loss. The fat redistribution may contribute to the improvements in
metabolic abnormalities.
|
| Language |
Greek, English |
| Subject |
Απεικονιστικές μεταβολές κοιλιακού λίπους |
|
Βαριατρική χειρουργική |
|
Παχυσαρκία |
| Issue date |
2016-03-24 |
| Collection
|
School/Department--School of Medicine--Department of Medicine--Doctoral theses
|
|
|
Type of Work--Doctoral theses
|
| Views |
238 |
Σωματομετρικές απεικονιστικές και βιοχημικές μεταβολές σε νοσογόνα παχύσαρκους ασθενείς πριν και μετά την απώλεια βάρους με επεμβατικές μεθόδους
