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Identifier uch.biology.msc//2006vaggelatos
Title Μελέτη της μετατόπισης προς την πυρηνική περιφέρεια των γονιδίων GAL1/10 σε συνθήκες μεταγραφικής ενεργοποίησης στο S. cerevisiae
Creator Vaggelatos, Giannis
Abstract Gene transcriptional activity is well correlated with intra-nuclear position, especially relative to the nuclear periphery, which is a region classically associated with gene silencing. Recently however, actively transcribed genes or inducible genes upon activation have also been found localized to the nuclear periphery in the yeast Saccharomyces cerevisiae. Here we studied the correlation between the nuclear topology and the transcriptional status of the glucose repressed, raffinose derepressed and galactose induced GAL gene locus. We found that the perinuclear confinement of this locus is neither necessary for transcription nor the consequence of mRNA synthesis. Furthermore, we have evidence suggesting that glucose derepression of the GAL1/10 promoter, even in the absence of galactose activation, is sufficient for the relocalization of the locus to the nuclear periphery. In any case, Tup1 is required for the perinuclear localization of the GAL1/10 genes, probably through its co activator rather than the co repressor mode of action.
Issue date 2006-11-0
Date available 2006-11-13
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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