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Identifier

000383136

Title

Ο ρόλος της πρωτεΐνης Gpx3 και του υπεροξειδίου του υδρογόνου (H2O2) στην οξειδωτική αναδίπλωση στο διαμεμβρανικό χώρο των μιτοχονδρίων

Alternative Title

The role of Gpx3 and hydrogen peroxide (H2O2) in oxidative folding in the mitochondrial intermembrane space

Author

Μαγκανά, Φανή

Thesis advisor

Τοκατλίδης, Κωνσταντίνος

Abstract

Mitochondria are considered to be essential organelles, responsible for a series of different procedures important for cell viability. One of the roles they are responsible for is the oxidative folding of protein molecules, a process performed primarily by the Mia40-Erv1 pathway. This well-described pathway is considered to be crucial for the oxidative folding of proteins that function in the mitochondrial intermembrane space. Recent studies in other sub-cellular compartments revealed that oxidative folding of proteins through a similar conserved pathway (PDI-Ero1) requires the presence of antioxidant proteins, such as PrxIV. The aim of this study was to elucidate the role of Gpx3, a well-known antioxidant protein recently found through proteomic analysis to reside in the mitochondrial intermembrane space, as part of an alternative redox regulation pathway.

Language

Greek

Subject

Mitochondria

Oxidative stress

Μιτοχόνδριο

Υπεροξείδιο του υδρογόνου

Issue date

2014-03-28

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses

Type of Work--Post-graduate theses

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