E-Locus - Institutional Repository of the University of Crete - Μελέτη των ιοντικών αλληλεπιδράσεων της αμινοτελικής περιοχής του συνυποδοχέα CCR5 του CD4+ T λεμφοκυττάρου με τη V3 περιοχή της γλυκοπρωτεΐνης gp120 του HIV-1

Home Μελέτη των ιοντικών αλληλεπιδράσεων της αμινοτελικής περιοχής του συνυποδοχέα CCR5 του CD4+ T λεμφοκυττάρου με τη V3 περιοχή της γλυκοπρωτεΐνης gp120 του HIV-1

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Identifier

000358530

Title

Μελέτη των ιοντικών αλληλεπιδράσεων της αμινοτελικής περιοχής του συνυποδοχέα CCR5 του CD4+ T λεμφοκυττάρου με τη V3 περιοχή της γλυκοπρωτεΐνης gp120 του HIV-1

Alternative Title

Study of ionic interactions between the aminoterminal region of the CCR5 coreceptor of CD4+ T lymphocytes with the V3 region of the gp120 glycoprotein of HIV-1

Author

Μπουντουράκη, Αφροδίτη Στυλιανού

Thesis advisor

Ρίζος, Απόστολος Κ.

Abstract

The applications and the use of synthetic peptides to treat human diseases are increasing rapidly, as well as the development of relevant technologies. Although we know the basic biology of the virus that causes AIDS (HIV-1), our information on how the virus causes the disease is limited. That is because the virus is highly dependent on its natural host, humans, and there aren’t good models to study the effect of the virus in relation to the disease. The problem that makes even more complex the issue of pathogenesis is that the majority of the cell population that is deleted by the presence of the virus in the body of the host is not infected. The prevailing view today is that the virus sensitizes the apoptotic pathways of these cells and leads them to programmed death. This phenomenon has been studied previously by our research team with synthetic peptides of the V3 region of the virus according to the physiological mechanism of antigen presentation. Therefore we developed a novel method to study specific mechanisms of the human immune system which confirmed that the V3 phenomenon is a general mechanism for the virus. The main purpose of this work is the study of chemokine receptor CCR5 who lies on the surface of activated T lymphocytes and the interaction of the V3 region with CCR5 by physicochemical methods, in particular laser light scattering spectroscopy. We have analyzed the behavior of these materials in physiological solutions and the influence of ionic forces/interactions as a function of the number of basic amino acids in the V3 region.

Language

Greek

Subject

CCR5

HIV-1

Ionic interactions

Laser light scattering

V3 region

V3 περιοχή

Ιοντικές αλληλεπιδράσεις

Σκέδαση ακτίνων laser

Issue date