Abstract |
The porpose of this study was to study the regeneration of the autotransplanted splenic tissue in the rabbit, and establish the functional status of the autotranslanted organism. 65 adult female New Zealand while rabbits were divided in four groups : Normal controls (A), Splenectomised(B), and Autotransplanted(C&D). We studied the ab;ility of the Polymorphonuclear leucocytes (PMN) for Phagocytosis, Intracellular killing, and production of Immunoglobulins. On the 12th week the animal underwent a mortality test by trastracheal inoculation of pneumococcus. All animals under went post-mortem and the regenerated autotransplanted spleen was studied and compared with the normal. The lungs, liver and adrenal were also studied histologically. The test revealed the following conclusions. 1-Splenectomy delays the phagocytic ability of the PMN by decreasing a plasma factor, but does not affect the ability of the PMN. 2- The autotransplanted splenic tissue at 12 weeks restores the ability of PMN for phagocytosis. 3- Absence of active splenic tissue results in decreasing rate of intracellular killing by the PMN and 4- The autotransplanted slenic tissue restores this ability. 5- Splenectomy results in decreasing the levels of IgM and IgG, where autotransplantation increases both immunoglobulins but failed to restore them to normal level. 6- Removal of the sleen makes the host susceptible to pneumococcal infrections.
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