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Identifier

000334300

Title

Μελέτη των συντηρημένων αλληλουχιών που δεν κωδικοποιούν πρωτεΐνες στα γονιδιώματα των ψαριών

Alternative Title

Conserved non-coding sequences in figh genomes

Author

Μανουσάκη Τερέζα

Thesis advisor

Λαδουκάκης, Μανώλης

Abstract

In the era of meta-genomics, conserved non-coding regions have attracted the researcher’s attention. They are believed, and in many cases proven, to play important key-role in the evolution of the vertebrates’ genome. In this study, we explored the intergenic, non-coding part of the genomes of 5 fish, Zebrafish, Fugu, Tetraodon, Medaka and Stickleback. We designed an algorithm which extracted the intergenic sequences of each genome, the conserved non-coding elements (CNEs) between them and compared them with those found in other studies and organisms. Fish contain only a few CNEs, 103, compared to other groups and other studies that used species with similar evolutionary distance. Half of them are shared with the other vertebrates while the other half seem to be fish-specific. An important fraction of their flanking genes are associated with regulation of transcription and development. They seem to be syntenic in most of the species we studied, they are mainly located near genes and also form clusters. Thus, we propose that the new set of fish-specific CNEs may play an important role in teleost evolution.

Language

Greek

Subject

CNEs

Comparative Genomics

Συγκριτική Γονιδιωματική

Issue date

2008-12-04

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses

Type of Work--Post-graduate theses

Views

283

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