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Identifier

000369184

Title

Μελέτη της επίδρασης συνθετικών ανάλογων του νευροστεροειδούς DHEA στον αποπτωτικό κυτταρικό θάνατο

Alternative Title

Study of the effects of neurosteroid DHEA synthetic analogs on adoptotic cell death

Author

Μπέσσα, Παρασκευή

Thesis advisor

Γραβάνης, Α.

Abstract

Neurodegenerative diseases and traumatic injuries in the central nervous system (CNS) are presented to be a silent epidemic situation of modern societies. Even though nowadays some of these situations can be characterised as treatable, still there is a long debate if they can also be curable. The last two decades, scientific indications gave rise to a more optimistic approach for drug development that will permit improvement and possible therapy for these pathological conditions, presenting at the same time a social and economical challenge worldwide. After fundamental research on the molecular mechanisms that control the axonal growth arrest in the CNS, neurotrophins have been identified as significant candidates possible to promote neuroregeneration. Recent studies on the neurotrophic receptors’ activation by specific neurosteroids produced in the CNS, revealed that DHEA and its synthetic analogs, present anti-apoptotic and neuroregenarative effects in vitro (cell cultures) and in vivo experiments promoting a possible neuroprotective role of the endogenous neurosteroids in neurodegenaration diseases. These findings provide the pharmacological basis for proposing a novel therapeutic approach by triggering different type of regeneration mechanisms in order to confront neurodegenerative diseases or injuries in the CNS.

Language

Greek

Subject

Apoptosis

Neurodegenerative diseases

Απόπτωση

Νευροεκφυλιστικές ασθένειες

Νευροστεροειδή

Issue date

2011-11-18

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses