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Identifier

000441897

Title

Μελέτη της σηματοδοτικής οδού STING στο λέμφωμα Hodgkin σε παιδιά και εφήβους σε σχέση με ενήλικες

Alternative Title

Comparative study of STING signaling in pediatric, adolescent and adult cases of Hodgkin lymphoma

Author

Γκούβα, Αφροδίτη

Thesis advisor

Δράκος, Ηλίας

Reviewer

Καλπαδάκη, Χριστίνα
Στειακάκη, Ευτυχία

Abstract

Hodgkin lymphoma (HL), the fist lymphoma ever described, is characterized by a minority of neoplastic lymphocytes (known as Hodgkin and Reed-Sternberg cells-HRS) embedded in a plethora of inflammatory non-neoplastic cells. Current immunotherapeutic data, including studies targeting the immunologic inhibitors PD1 or PD-L1 suggest that activation of immunologic mechanisms can augment the therapeutic potential of traditional chemotherapeutic treatment in HL, reducing the subset of patients that succumb to the disease. Recent studies suggest that STING, a central adaptor protein orchestrating a natural immunity signaling pathway emanating from DNA-cytoplasmic signals, is important for anti-tumor immune response. However, the expression profile of STING and the biologic significance of the STING pathway in HL is unknown. Using archive, formalin-fixed paraffin embedded HL tissues and immunohistochemical methods we showed that STING is differential expressed in the neoplastic and reactive cells in HL tumors. We found that the STING signaling pathway is activated in HRS cells in a subset of HL tumors. In addition, the levels of STING expression in HRS cells were inversely associated with the levels of PD-L1 expression in inflammatory background cells in HL tumors. Also, there was no significant difference in the levels of STING expression between adult and pediatric HL tumors. Our findings suggest that the STING signaling pathway may be involved in the antitumor immune response in HL. The mechanisms regarding STING activation anf the prognostic significance of STING expression and activation in HL merits further investigation.

Language

Greek

Issue date

2021-07-29

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses

Views

287

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