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Identifier

000451980

Title

Study of the effect of auxetic meta-materials on macrophages polarization

Alternative Title

Μελέτη της επίδρασης αυξητικών μετα-υλικών στη διαφοροποίση των μακροφάγων

Author

Παραγεωργίου, Μαρία Ε.

Thesis advisor

Ρανέλλα, Ανθή

Reviewer

Αθανασάκη, Ειρήνη
Βελώνια, Καλλιόπη

Abstract

In the last decades, biomaterials are being designed to be inert in the organism so as to prevent an immune-response from the host, in this context, the latest advances in tissue engineering and regenerative medicine allow for the design of ‘immuno informed’ biomaterials that can positively interact with the immune system upon implantation. This can be achieved by tailoring the mechanical, chemical and topographical properties of the biomaterial in order to dictate a favourable macrophage response, as macrophages have been proven to play a very important role in healing due to their ability to polarize into pro-inflammatory (M₁) or/and anti inflammatory (M₂) phenotypes. While many studies focus on examining the macrophage response to different biomaterials, the effect of three-dimensional materials on macrophage polarization has yet to be thoroughly examined. This study aims to closely examine the effect of three-dimensional auxetic meta-materials, designed to have specific properties (like negative Poisson ratios), on the polarization of macrophages into their different phenotypes.

Language

English

Subject

Immunomodulation

Immunoresponse

Regenerative medicine

Scaffolds

Tissue engineering

Αναγεννητική ιατρική

Ανοσοαπόκριση

Ικριώματα

Μακροφάγα