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Identifier

000383317

Title

Σύνθεση νέων πορφυρινικών συμπλόκων με περιφερειακούς δεσμούς θείου για βιοεφαρμογές

Alternative Title

Synthesis of new porphyrins derivatives bearing sulfur bonds for bio-applications

Author

Καρίκης Κωνσταντίνος-Τσαμπίκος

Thesis advisor

Κουτσολέλος, Αθανάσιος

Reviewer

Κιτσόπουλος, Θεοφάνης
Μητράκη, Άννα

Abstract

Self-assembled porphyrins moieties widely exist in photosynthetic proteins serving as active species in the initial steps of light energy conversion. It is also well-known that thiols ,disulfides,thioacetyl and thiocyanic groups could be covalently linked to the surface of gold by Au-S binding to form highly ordered self-assembled monolayers (SAMs). SAMs of thiol-derivatized porphyrins on Au substrates have attracted extensive interest and studied accordingly because of the unique optical/electronic properties of the SAMs as well as their excellent stability, so that they have been broadly applied in sensing, molecular recognition, catalysis, and molecular electronics. Self-assembled chromophore systems are widely accepted for the construction of novel photochemical and electrochemical materials and also have recently become one of the most important issues in the fields of materials science and nanotechnology. Molecular components self-assemble to form unique structures possessing high functionality. Therefore, the rational design of the functional repeating units is important for the resulting structures and performance of the self-assembled materials In the present study, novel meso-substituted porphyrin moieties have been prepared, where porphyrin units possess thioacetyl protecting groups. Also the experimental procedures for the synthesis of a series of porphyrins with cyanuric chloride as a substituent, are described. Afterwards two new porphyrins with maleimide terminus have been synthetized , and then they were bio-conjugated with peptides and the self organization of the resulting dimer moieties were investigated All organic compounds were characterized using NMR spectroscopy (¹H, ¹³C, COSY, HMBC and HMQC), UV-Vis, Fluorescence, Mass (Maldi-Tof), LEPIS spectroscopies and Transmission electron microscopy (TEM).

Language

Greek

Subject

Bioconjugation

Gold surface

Organic dyes

Peptides

Porphyrin

Thioacetyl protecting groups

Βιοσύζευξη

Επιφάνειες χρυσού

Οργανικές χρωστικές