E-Locus - Institutional Repository of the University of Crete - Μελέτη του ρόλου του υποδοχέα PD-1 στην διατήρηση της περιφερικής ανοχής

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Identifier

000334460

Title

Μελέτη του ρόλου του υποδοχέα PD-1 στην διατήρηση της περιφερικής ανοχής

Alternative Title

Study of biological processes with fluorescence molecular tomography

Study of the role of PD-1 receptor in peripheral tolerance

Author

Οικονομάκη, Αικατερίνη

Thesis advisor

Μαμαλάκη, Κλειώ

Abstract

The balance between stimulatory and inhibitory signals is required for effective immune responses to pathogens and for maintaining self-tolerance. Signals through the B7/CD28 family are major regulators of this critical balance, because the pathways in the B7/CD28 family provide second signals that can regulate the activation, inhibition, and fine-tuning of T-cell responses. To the B7/CD28 family of interactions also belong the PD-1/PD-L interactions. The PD-1 receptor is inducibly expressed on T cells after their activation and delivers inhibitory signals to them. Purpose of this research is to study the role of PD-1 in the induction and maintenance of the tolerance of the CD8 T cells. In the transgenic animal that is used the CD8 T cells express a transgenic TCR receptor (F5) which specifically recognizes the NP 366-374 protein of the influenza virus. In the same animal is also expressed the NP 366-374 protein as a self antigen. As a result the F5 Tcells encounter the antigen during the development of the animal and recognize it as a normal self antigen. Therefore in the peripheral lymphoid organs F5 T cells are tolerized either by clonal deletion or anergy. In this transgenic model it is possible to follow the fate of CD8 Tcell responses to self antigens in the absence and presence of PD-1 receptor.

Physical description

43 σ. : εικ. ; 30 εκ.

Language

Greek

Subject

λεμφοκύτταρα

T cells

transgenic model

διαγονιδιακό μοντέλο

Issue date

2008-12-04

Collection