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Identifier G00148
uch.med.phd//1997lydaki
Title Κάθαρση μυελού παίδων με νεοπλασίες με τη χρήση φωτοδυναμικής θεραπείας
Alternative Title Bone marrow purging in children with molignant diseases by the use of protodynamic therapy
Creator Lydaki, Evaggelia S
Creator Λυδάκη Ευαγγελία Σοφοκλής
Contributor Σχολή Επιστημών Υγείας Τμήμα Ιατρικής.
Abstract We studied the effect of Mc540 phototradiation on both neoplastic and norutal houcpoietic progenitor cells. Bone marrow cells front 26 children with acute lenkemias, ALL in remission and normaly children as weel as of Rch-6 and HC-60 all lines were incubated with Mc 540 in the presence or absence of human albumus and expesed to Laser light (Argon 514nm or Nd-Yag) A99.9999% inhibition of Reh-6 and HL-60 was noted at irydiation doses where corresponducy mean survival of BM cells was 80.6 +- 4% and 74.3 +-2.8% respectively (liggid cultures) fresh bone marrow shampuls from children with acute lenkemias were also very sensitive to Mc 540 photorractiation although variability was abserved in the sensitively to Mc 540. The survival of normal bone marrow progenitors from children with ALL in remission was 22% for CFU-E, 36% for BFU-E, 38% for CFU-GM and 26% for CFU- GEMM. H.A. protects normal haucpoietic cells from Mc 540 mediated phototoxicity and it has minimal effect on the survival of neoplantic cells at doses < =0.25%.
Physical description 142 σ. --
Subject 1. κάθαρση μυελού 2. νεοπλασίες παιδίων 3. φωτοδυναμική θεραπεία 4. Μεροκυανίνη 540 5. μεταμόσχευση μυελού των οστών 6. bone marrow purging 7. childhood malignancies 8. photodynamic therapy 9. Merocyanine 540 10. bone marrow transplantation
Issue date 1997-05-01
Date available 1998-04-5
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Notes Committee Members Καλμαντή, Μαρία, Τόσκα, Ανδρονίκη, Χελιδόνης, Εμμανουήλ, Ηλιόπουλος, Γεώργιος, Σμπυράκης, Στέλιος, Δελίδης, Γεώργιος, Τσιλιμπάρης, Μιλτιάδης
Number of References 261. --
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