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Identifier

000423877

Title

Investigating the role of dendrites in pattern completion by means of computational modeling

Alternative Title

Μελετώντας το ρόλο των δεντριτών στον μηχανισμό ολοκλήρωσης προτύπου με τη χρήση υπολογιστικών μοντέλων

Author

Πάγκαλος, Μιχαήλ Κ.

Thesis advisor

Ποϊράζη, Παναγιώτα

Reviewer

Σιδηροπούλου, Κυριακή
Καραγωγέως, Δόμνα

Abstract

Pattern completion is the process that allows a memory to be retrieved by partial or degraded recall cues. Numerous theoretical studies, based on empirical data, suggest that the CA3 area of the hippocampus allows the storage of autoassosiative memories, due to its large number of recurrent excitatory connections. Although synaptic plasticity in the CA3-CA3 synapses is considered as the major underlying mechanism, recent experimental evidence suggests that active dendritic processes could also be involved. Thus, we argue that a more detailed understanding of the mechanisms supporting memory recall through pattern completion should be established. Towards this goal, we developed a simplified spiking model of the CA3 area, which consists of multicompartmental pyramidal cells along with point inhibitory populations. To ensure its biological validity, a large amount of electrophysiological data was taken into consideration. Our model allows us to perform simulations of memory “storage and recall” and estimate pattern completion performance under diverse sets of conditions. Here, we provide new insight on how NMDAR-mediated nonlinearities contribute to the emergence and robustness of pattern completion. Furthermore, we make some predictions on how the nature of dendritic integration might affect the computational properties and behaviour of the CA3 network.

Language

English

Subject

Computational neuroscience

Dendrites

Hippocampus

Pattern Completion

Δενδρίτες

Ιππόκαμπος

Συμπλήρωση προτύπου

Υπολογιστικές νευροεπιστήμες

Issue date