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| Identifier |
000369225 |
| Title |
Μελέτη του μηχανισμού της μιτοφαγίας στον νηματώδη Caenorhabditis elegans |
| Alternative Title |
The role of Mitophagy in Caenorhabditis elegans |
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Author
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Παληκαράς, Κωνσταντίνος
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Thesis advisor
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Ταβερναράκης, Νεκτάριος
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Reviewer
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Παπαματθαιάκης, Ιωσήφ
Σπηλαινάκης, Χαράλαμπος
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| Abstract |
Mitochondria are ubiquitous membrane – bound organelles and they are a defining feature of
eukaryotic cell. The organelle is composed of a soluble matrix surrounded by a double
membrane, an ion impermeable inner membrane and a permeable outer membrane. Despite the
fact that mitochondria contain their own independent genome, they are characterized as semiautonomous
organelles because their biological functions rely on the expression of nuclear genes.
The mitochondrion is the site where electron transport chain and oxidative phosphorylation take
place and provides the cell with the essential energy in the form of ATP for many cellular
activities. Also, mitochondria are the major source of cellular reactive oxygen species (ROS) that
cause oxidative damage to mtDNA, proteins and lipids. Accordingly, damaged, aged and excess
mitochondria are a risk factor for the cell and proper elimination of them is important to maintain
cellular homeostasis. Mitochondrial quality control mechanisms are therefore indispensable to
cell survival and these include the removal of damaged mitochondrial proteins by an intra –
organelle proteolytic system, the repair of damaged mitochondria by healthy ones through fission
and fusion events and the removal of severely damaged mitochondria by autophagy (mitophagy).
Mitophagy is a selective type of autophagy and the major degradative pathway for mitochondrial
turnover. Little is known about the role of mitophagy in chronological ageing. During this thesis
we examined the requirement for mitophagy process during ageing in Caenorhabditis elegans
and we established an in vivo imaging system for monitoring mitophagy upon specific stimuli.
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| Language |
Greek |
| Subject |
Ageing |
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Autophagy |
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C. elegans |
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Αυτοφαγία |
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Γήρανση |
| Issue date |
2011-11-18 |
| Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
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Type of Work--Post-graduate theses
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| Views |
249 |
Μελέτη του μηχανισμού της μιτοφαγίας στον νηματώδη Caenorhabditis elegans
