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Identifier 000423630
Title Comparative analysis of potential new gene-targets for pesticides
Alternative Title Έυρεση γονιδίων στόχων στο πεπτικό σύστημα Myzus Persicae και Nezara Viridula
Author Ακάλεστου, Αλεξία
Thesis advisor Τοπάλης, Παντελής
Reviewer Παυλίδης, Παύλος
Ηλιόπουλος, Ιωάννης
Abstract The present work explores a comparative analysis of Myzus persicae genes in order to find new potential gene-targets for insecticide use in the gut. In order to compare the gene expression in anatomical structures of the gut and the carcass, an automated pipeline incorporating a series of tools to perform the analysis was developed. The results of the analysis were then visualized to obtain a better understanding of the outputs quality (PCA, dendrograms and pie charts) and expressions levels . As a final step of this project we had to find a way to determine which genes, out of these differentially expressed ones, could be used as potential drug targets. Ideally these genes could then be used for an effective pest control management with the help sequence-specific gene silencing via RNA interference (RNAi). In order to achieve this we implemented a Machine Learning approach which included both Classification and Clustering methods.
Language English
Subject RNA seg
Μηχανική μάθηση
Issue date 2019-07-17
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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