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Identifier

000369174

Title

Μελέτη του ρόλου των φλοιθαλαμικών ινών στην ανάπτυξη του εγκεφάλου σε γενετικά τροποποιημένα μοντέλα

Alternative Title

Study of the role of corticothalamic fibers in mouse brain development

Author

Θεοδοσίου, Μαρίνα

Thesis advisor

Καραγωγέως, Δόμνα

Abstract

The cerebral cortex is a very complex structure, which is characterized by the presence of cortical circuits. Cortical circuits play a key role in the function of the cerebral cortex. Cortex receives the major sensory input from the thalamus through thalamocortical axons and sends information to other brain structures, like the spinal cord. Furthermore, neurons in the cortex creat circuits between neurons in the same hemisphere (corticocortical axons) or the opposite hemisphere (callosal axons). The environment of the axons is essential for their navigation to their target. Signaling molecules and transcription factors, which are expressed with graded concentrations in the cortex are important to establish the cortical maps of topography. For the thalamocortical connection, based on the handshake hypothesis, the interaction between the two different types of axons is very important. Early generated corticofugal axons from the subplate pioneer neurons interact with thalamocortical axons and compose a scaffold for their navigation. However, we do not know yet if this interaction is essential for the navigation of both set of axons. TAG-1 protein is expressed early in the development by pioneer neurons and specifically in their axons. In this study, using the transgenic mice Tag1^{loxP-GFP-loxP-DTA} and Emx1^Cre, we tried to study the role of ΤΑG-1 corticofugal axons in the cerebral cortex development and their role in the establishment of thalamo-cortical circuit.

Language

Greek

Subject

Cortex

Thalamocortical axons

Thalamus

Θάλαμος

Θαλαμοφλοιϊκοί άξονες

Φλοιοθαλαμικοί άξονες

Φλοιός

Issue date

2011-11-18