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Home    Εντοπισμός της πρωτεϊνης Fras1 στο αναπτυσσόμενο ΚΝΣ των ποντικών και συσχέτιση με τις μοριακές αλλαγές στον Fras1 εγκέφαλο  

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Identifier 000369252
Title Εντοπισμός της πρωτεϊνης Fras1 στο αναπτυσσόμενο ΚΝΣ των ποντικών και συσχέτιση με τις μοριακές αλλαγές στον Fras1 εγκέφαλο
Alternative Title Identification of Fras1 in the developing CNS in mouse and correlation with molecular defects in Fras1 Brains
Author Καλογεράκη, Ευγενία
Thesis advisor Χαλεπάκης, Γιώργος
Abstract Basement membranes are sheet like arrangements rich in extracellular matrix proteins that serve a variety of functions including the physical separation of cell layers and tissues. Fras1 protein is located in the basement membrane of several mouse epithelia during embryonic development and plays an important role in the establishment of a functional epithelial/mesenchymal adhesion. According to previous results, Fras1 is expressed in areas of the brain which play an important role in processes such as the memory of emotional reactions. Here we investigate areas where Fras1 protein is localized in brains of mice embryos. We found that Fras1 is localized at pia mater following a discontinuous pattern. Also, Fras1 protein is detected at choroid plexus. Fear conditioning experiments have revealed that Fras1-/- mice have defective memory of fear. This circuit involves various areas such as amygdala, hippocampus and cortex. To determine if there are cellular defects in those mice we studied the cortex with molecular markers. Our results reveal that there are disturbances in allocation of some cellular types in the cortex.
Language Greek
Subject Basement membrane
Choroid plexus
Cortex
Pia mater
Βασική μεμβράνη
Φλοιός
Χοριοειδές πλέγμα
Χοριοειδής μήνιγγα
Issue date 2011-11-18
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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