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Identifier uch.med.phd//1994DIS0054
Title Φωτοθρόμβωση της νεοαγγείωσης του κερατοειδούς κουνελιών με τη βοήθεια φθαλοκυανίνης και διοδικό laser
Alternative Title Corneal neovascularization photothrombosis in rabbits by means of phthalooxanine and a diode laser
Creator Tsilibaris, Miltiadis K
Abstract The aim of our study was to evaluate the effectiveness of Albino rabbits corneal neovascularization photothrombosis by means of phthalocyanine and a diode laser. Our results demonstrated that phthalocyanine when irradiated by a low power diode laser(2-7MW)emitting at 670-675 nm leads to photodynamic thrombosis of corneal neovascularization. The rate of thrombosis correlated to chloroaluminum tetrasolfonated phthalocyanine administered dose(3-14 mg/Kgr). It was shown that irradiation should be initiated the first minutes after phthalocyanine injection. The induced intravascular thrombus was composed mainly by aggragated platelents and seemed to result from vascular endothelial cell photochemical damage. The plasmatic membrane of these cells seemed to be one of the first sites damaged by photodynamic therapy.
Issue date 1994-05-01
Date available 1997-06-6
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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