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Home    Αυξημένη ευαισθησία των Β-λεμφοκυττάρων του περιφερειακού αίματος σε μη ειδικούς πολυκλωνικούς διεγέρτες σε πάσχοντες από χρόνια ιδιοπαθή ουδετεροπενία  

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Identifier 39631
Title Αυξημένη ευαισθησία των Β-λεμφοκυττάρων του περιφερειακού αίματος σε μη ειδικούς πολυκλωνικούς διεγέρτες σε πάσχοντες από χρόνια ιδιοπαθή ουδετεροπενία
Creator Andrioti, Chrysi V
Abstract The current study was designed to investigate some quantitative and functional parameters of B-lymphocytes in patients with chronic idiopathic neutropenia (CIN) of adult. The study was carried out on 107 patients and 46 normal controls. We found that patients had increased proportions of peripheral blood B- lymphocytes but normal absolute B-lymphocyte counts, a discrepancy probably due to lymphopenia caused by the reduction of T- and NK-cells previously reported. Patients had also increased proportions of CD19+ bone marrow B-lymphocytes. Peripheral blood CD19+/CD23+ cells, representing the activated B-lymphocyte population, were not increased in the patients studied, and serum soluble CD23 molecules normally seeded from activated B-lymphocytes, did not differ from the controls. Patient immunomagnetically isolated peripheral blood CD19+ B-lymphocytes displayed a significantly raised sensitivity to nonspecific polyclonal mitogens, as evidenced by the high amounts of soluble CD23 molecules seeded in the supernatant culture medium. We suggest that all these findings are probably related to a low-grade chronic inflammatory process in CIN patients leading to chronic antigenic stimulation, as we previously have reported
Language Greek
Issue date 2003-04-01
Date available 2003-07-21
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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