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Identifier

000376372

Title

Study of the antiviral properties of CD40L during lytic infection by herpes simlex Virus type (HSV-1)

Alternative Title

Μελέτη της αντιικής δράσης του CD40L κατά τη διάρκεια λυτικής λοίμωξης από τον ιό του απλού έρπητα τύπου 1 (HSV-1)

Author

Vlachava, Virginia-Maria

Author

Βλαχάβα, Βιργινία-Μαρία

Thesis advisor

Σουρβίνος, Γεώργιος

Reviewer

Ηλιόπουλος, Αριστείδης

Abstract

Herpes simplex virus type 1 (HSV-1) is a neurotropic, alpha herpesvirus that belongs to the Herpesviridae family. Similar to other viruses, it utilizes the host cell machinery in order to orchestrate its life cycle. In order to do so, it follows a well organized pattern of viral gene expression which is modulated according to the environmental conditions. Thereby, HSV-1 can evade immune responses, apoptosis and also modulate histone modifications in order to switch from an active to a latent state and vice versa. Several approaches have been made towards the elucidation of HSV-1 biology and to identification of targets for its treatment. In this context, CD40 and CD40 ligand have also been studied since their signaling is of major importance in the immune system. Experiments in mice have revealed severely compromised humoral immune responses in the absence of CD40L while a direct antiviral effect has been demonstrated in cells expressing CD40. To that direction, we attempted to investigate the effect of CD40-CD40L signaling to HSV-1 infection and how this affects viral protein expression during lytic infection. We indeed, observed a reduction in viral yield upon treatment with CD40L as well as some decrease in the protein expression of the virus early protein ICP8.

Language

Greek

Subject

CD40

CD40L

HSV-1

Herpesviruses

Virology

Έρπης

Issue date

2010-12-14

Collection