| Abstract |
The aim of this study was to contribute to the research of alternative ways of prophylactic antibiotic administration. This was achieved by studying the differences in effectiveness between classical preoperative intravenous administration and that of intraparietal administration. The comparison mainly concerned the differences between the pharmacokinetics of these two ways of administration and the clinical effectiveness. One hundred and two patients were studied. These patients were split in a random way into two groups, one of 52 and another of 50 patients. In the first group, Cefriaxone 2 gr was administered intravenously prior to operation. In the second group the same dose of the antibiotic was administered subcutaneously along the line of the proposed abdominal incision. According to the results of the study of pharmacokinetics, plasma levels of the drag was comparable, regardless of the technique used, six hours after administration and these levels exceeded the minimum inhibitory concentration of most aerobic and anaerobic gram- positive and negative organisms. The result of this was that there was no difference in septic complications occurring at other sites. Intraparietal administration as it can be seen by the study of pharmacokinetics and by analyzing clinical outcome of patients, is clearly superior regarding wound site infection, that is three times less than that of intravenous administration. This is the result of high antibiotic concentration found at the site of surgical wound at the time of wound closure. As a result, we suggest the administration of 2gr of ceftriaxone intraparietaly just before the introduction of the anesthesia in order to reduce the postoperative wound sepsis
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Συγκριτική μελέτη του αποτελέσματος της προεγχειρητικής χημειοπροφύλαξης μεταξύ ενδοφλεβίου και ενδοτοιχωματικής χορήγησης
