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Identifier

000426722

Title

The effect of developmental ablation of TAG-1-expressing pyramidal neurons in the mouse brain

Alternative Title

Αποτέλεσμα της απαλοιφής των νευρώνων που εκφράζουν TAG-1 στον αναπτυσόμενο φλοιό των ποντικών

Author

Μαριάτος Μεταξάς, Δημήτριος Γ.

Thesis advisor

Καραγωγέως, Δόμνα

Reviewer

Μπέρτσιας, Γεώργιος
Σιδηροπούλου, Κυριακή

Abstract

Corticofugal axons projecting to the thalamus, stiatum and palidum are known to express (CNTN2/TAG-1), a neuronal recognition molecule of the immunoglobulin superfamily involved in neurogenesis, neurite outgrowth and fasciculation. TAG-1, which is expressed transiently by cortical pyramidal neurons during embryonic development, has been shown to be fundamental for axonal recognition and cellular migration in the developing cortex. Our lab generated a novel mouse line that enables us to track the neurons expressing Tag-1 and, upon crossing with the EMX1cre line, to ablate the vast majority of Tag-1 expressing neurons in the cortex. This model revealed to us that Tag-1-expressing neurons are also located in superficial layers projecting to other cortical areas and contributing to the formation of the corpus callosum. The ablation of Tag-1-expressing cells resulted in defective development of major fiber tracts such as the corpus callosum and anterior commissure. Furthermore, we observed reduced number of interneurons in the cortex. Tag-1DTA mutant mice displayed better learning abilities but defective spatial memory.

Language

English

Subject

Anterior commisure

CNTN2

Corpus callosum

Migration

Μεσολόβιο

Πρόσθια δεσμίδα

Issue date

2019-11-29

Collection