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Home    O ρόλος της κινάσης Τpl2 στο σηματοδοτικό μονοπάτι των ιντεγκρινών και η σημασία της στην φλεγμονώδη αντίδραση  

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Identifier 000326757
Title O ρόλος της κινάσης Τpl2 στο σηματοδοτικό μονοπάτι των ιντεγκρινών και η σημασία της στην φλεγμονώδη αντίδραση
Author Ιωάννου, Μαριάννα
Thesis advisor Τασιούλας, Ιωάννης
Thesis advisor Μπούμπας, Δημήτριος Τ
Abstract Integrin function is essential for the function of neutrophils and macrophages, key effector cells during the innate immune response. Integrin signaling is critical for cellular functions such as firm adhesion, cell spreading, chemotaxis and the production of various cytokines. Exaggerated inflammatory responses occur when integrins are inappropriately activated. Thus, tight control of integrin signaling and function is required for appropriate coordination of innate immune and inflammatory responses. Signaling pathways activated downstream of integrins include the p38, ERK1/2 and JNK MAPKs among others. Tpl2 is a MAP3K that has been shown to preferentially regulate activation of ERK1/2 MAPKs and pro-inflammatory cytokine production in response to LPS. We sought to evaluate the role of Tpl2 kinase in the integrin signaling pathway and macrophage functions such as adhesion, spreading and cytokine production after integrin stimulation. Experiments performed on murine and human macrophages, indicate that Tpl2 kinase is required for integrin-induced ERK1/2 MAPK activation, cell spreading and cytokine and chemokine production in primary macrophages. Our data identify Tpl2 as part of the integrin signalosome that is formed in adherent macrophages. Tpl2 may represent a potential therapeutic target in systemic inflammatory/autoimmune diseases where aberrant integrin function may play a pathogenic role.
Language Greek
Issue date 2008-04-07
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
Notes Διατμηματικό Πρόγραμμα Mεταπτυχιακών σπουδών: «Μοριακή Βιολογία και Βιοιατρική»
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