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Identifier

uch.med.phd//1995papadaki

Title

Serum levels of soluble interleukin - 6 receptor (SIL - 6R) in patient s with myelomatosis and monoclonal eammopathy of undetermined scienifi cance

Alternative Title

Κλινική σημασία συγκεντρώσεων του διαλυτού υποδοχέα της ιντερλευκίνης - 6 (SIL - 6R) στον ορό των πασχόντων από μυελωματική νόσο

Creator

Papadaki, Eleni, A

Contributor

ΤΜΗΜΑ ΙΑΤΡΙΚΗΣ

Abstract

We measured with an ELISA immunoassay the levels of soluble interleukin-6 receptor (SIL-6R) in the serum of 40 patients with multiple myeloma and also the serum of 10 patients with other plasma-cell dyscrasias. We found that SIL-6R levels were increased by 40% in patients with multiple myeloma. No significant correlation between SIL-6R levels and serum IL-6, TNFa or albumin levels could be demonstrated but we found a highly significant positive correlation between SIL-6R levels and other previously recognized prognastic factors such as B2m, CRP, creatinine, fernitin and LDH. We also found that SIL-6R levels in multiple myeloma patients reflect the activity of the disease, but they cannot be used as a prognostic factor regarding survival

Physical description

110

Language

Greek

Subject

: 1. ΙΝΤΕΡΛΕΥΚΙΝΗ - 6 2. ΥΠΟΔΟΧΕΑΣ ΙΝΤΕΡΛΕΥΚΙΝΗΣ - 6 3. ΜΥΕΛΩΤΙΚΗ ΝΟΣΟΣ 4. INTERLEUKIN - 6 5. SOLUBLE INTERLEUKIN - 6 RECEPTOR 6. MYELOMATOSIS 7. MONOCLONAL GAMMOPATHY OF UNDETERMINED SIENIFICANCE

Issue date

1995-06-01

Date available

1997-06-6

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

Notes

Committee Member ΑΝΑΓΝΟΥ, ΝΙΚΟΛΑΟΣ

Committee Member ΓΕΩΡΓΟΥΛΙΑΣ, ΒΑΣΙΛΕΙΟΣ

Committee Member ΗΛΙΟΠΟΥΛΟΣ, ΓΕΩΡΓΙΟΣ

Committee Member ΚΑΛΜΑΝΤΗ, ΜΑΡΙΑ