Your browser does not support JavaScript!

Home    Το NALP3 φλεγμονόσωμα και ο ρόλος του στις ιδιοπαθείς φλεγμονώδεις νόσους του εντέρου (ΙΦΝΕ)  

Results - Details

Add to Basket
[Add to Basket]
Identifier 000361143
Title Το NALP3 φλεγμονόσωμα και ο ρόλος του στις ιδιοπαθείς φλεγμονώδεις νόσους του εντέρου (ΙΦΝΕ)
Alternative Title NALP3 inflammasome and its role in inflammatory bowel diseases (IBD)
Author Κοντάκη Ε.
Thesis advisor Παπαδάκης, Κ.
Σιδηρόπουλος, Π.
Abstract NALP3 protein belongs to the NLR (NOD-like receptor) subfamily, a newly identified cytosolic pattern recognition receptor (PRR) protein group. In response to various exogenous and endogenous danger signals, NALP3 forms a multiprotein platform, called NALP3 inflammasome, which activates the inflammatory caspase-1 leading to maturation of IL-1β and IL-18. In Crohn’s disease (CD) the production of these two cytokines is elevated, while NOD2, another member of the NLR subfamily, is the main susceptibility locus for the disease. More interestingly, NALP3 polymorphisms as well as combined variants of NALP3 and CARDINALcomponents of NALP3 inflammasome- have recently been identified as risk factors for developing CD. These data indicate the involvement of NALP3 inflammasome in the pathogenesis of CD. Here, we showed that NALP3 inflammasome activation upon LPS plus ATP has no difference between healthy controls and CD patients, while activation upon MDP was more evident in CD patients. Intriguingly, CD colonic tissue expressed bioactive caspase-1 contrary to normal colonic specimens. Furthermore, we found that mice lacking NALP3 gene were highly susceptible to DSS colitis, although the mechanism driving colonic inflammation was poorly understood.
Physical description 46 σ. : πιν. ; 30 εκ.
Language English
Subject Inflammatory bowel disease
NALP 3 φλεγμονόσωμα
NALP3 inflammasome
Proteins
Ιδιοπαθείς φλεγμονώδεις νόσοι του εντέρου
Πρωτεϊνες
Issue date 2009-12-14
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Notes Πρόγραμμα μεταπτυχιακών σπουδών: "Μοριακή βάση των νοσημάτων του ανθρώπου"
Views 203

Digital Documents
No preview available

Download document
View document
Views : 19