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Identifier 000360968
Title SATB1 as a candidate player in the process of interchromosomal interactions
Alternative Title Μελέτη της πρωτείνης SATB1 ως συμμετέχων μόριο στη διαδικασία των διαχρωμοσωμικών αλληλεπιδράσεων
Author Σαρρής, Μιχάλης
Thesis advisor Σπηλιανάκης, Χαράλαμπος
Abstract Epigenetic phenomena regulate the differentiation of naïve CD4 cells to Th1 and Th2 cell lineages. Intra and interchromosomal interactions between distal regulatory regions have been reported to contribute to this developmental switch, exhibiting a novel mode of regulation highlighting the importance of higher order chromatin structure. SATB1 (special AT-rich sequence binding protein 1) is a well known chromatin organizer protein that packages chromatin into loops to coordinate the expression of the underlying genes. Here we report SATB1 expression in naïve CD4 cells and show that this architectural protein participates to the complex phenomenon of interchromosomal interaction of genomic loci. Moreover we report the colocalization of SATB1 with Lamin-A in the nucleus of CD4 cells and thymocytes.
Language English
Subject Διαχρωμοσωμικές Αλληλεπιδράσεις
Issue date 2010-11-19
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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