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| Identifier |
000408562 |
| Title |
Investigating the function of Regulator G-Protein Signaling 4 (RGS4) protein in central nervous system under chronic inflammatory pain |
| Alternative Title |
Μελέτη λειτουργίας της RGS4 πρωτεΐνης στο κεντρικό νευρικό σύστημα σε συνθήκες χρόνιου φλεγμονώδη πόνου |
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Author
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Αβράμπου, Κλεοπάτρα Π.
|
|
Thesis advisor
|
Ηλιόπουλος, Αριστείδης
|
|
Thesis advisor
|
Δελιδάκης, Χρήστος
Ποϊράζη, Παναγιώτα
|
| Abstract |
Around 10-15% of the population worldwide experience chronic pain induced by persistent inflammation.
Part of the reason that
the current therapeutic strategies are insufficient
or produce
major side effects,
has to do with
the incomplete
understanding
of molecular events involved in
development and
maintenance of chronic pain states.
Our research focus on
inflammatory pain.
Increased progress has
been made in understanding the molecular and
cellular mechanisms that drive the sensory input to the
spinal cord, whereas studies on signaling pathway adaptations in the brain centers are lacking. G-Protein
Coupled Receptor
(GPCR)
signaling pathways are highly implicated in pain hypersensitivity and
Regulator
of G-protein signaling (RGS) proteins play a central modulatory action on
these
GPCR-mediated cascades.
Previous studies
from our laboratory have established that
RGS4 is a positive modulator of analgesic
responses to tricyclic antidepressant drugs, a class of drugs widely prescribed for the treatment of
neuropathic pain conditions. Here, by using Mus Musculus
model
organism and well
-
established pain
behavioral assays we report
a functional role of RGS4 under chronic inflammatory
pain
states.
Interestingly, we reveal that RGS4 act in a modality specificity manner.
The regulation of RGS4 mRNA
levels in various pain related CNS regions, further, support our observed phenotype under persistent
inflammatory pain.
Using advanced gene targeting approaches, we
identified
the critical brain region
where RGS4 acts
to modulate
persistent inflammatory
pain
-
like states
.
Our study provides
novel insight
on
the role of RGS4 in intracellular adaptions
in brain regions
under
ling
chronic inflammatory pain
,
pointing to novel
targeted
pharmacological interventions for the alleviation of chronic pain conditions.
|
| Language |
English |
| Subject |
Χρόνιος φλεγμονώδης πόνος |
| Issue date |
2017-03-17 |
| Collection
|
School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
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|
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Type of Work--Post-graduate theses
|
| Views |
327 |
Investigating the function of Regulator G-Protein Signaling 4 (RGS4) protein in central nervous system under chronic inflammatory pain
