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Identifier 000383259
Title Ανάπτυξη και αξιολόγηση υπολογιστικών μεθόδων ανίχνευσης πρωτεϊνικών αλληλεπιδράσεων
Alternative Title Design and evaluation of computational methods for detecting protein-protein interactions
Author Μαξούρη, Στυλιανή
Thesis advisor Τζαμαρίας, Δημήτριος
Ηλιόπουλος, Ιωάννης
Abstract The recent advantages of high throughput technologies, in combination with the availability of fully sequenced genomes, have led to large-scale studies of maps toward the deeper understanding of the interactome of an organism. Interactome mapping scan stands as a powerful tool since information about the function of uncharacterized proteins or interacting domains aids experimentalists to design more targeted experiments. Since large-scale studies for protein-protein interaction (PPI) detection are not always applicable, there has been an effort to develop computational methods for predicting PPIs. These methods exploit either the available genomic or molecular data, or the available literature to extract information about PPIs. The aim of this project is the experimental evaluation of an existing computational approach for extracting PPIs from biomedical literature and the development of an additional approach for extracting PPIs from genomic data, in this case fusion events. The development of such tools will assist end-users in tackling the complexity of understanding molecular relationships in living systems.
Language Greek
Subject Gene fusion
Literature mining
Εξόρυξη δεδομένων
Πρωτεϊνικές αλληλεπιδράσεις
Σύντηξη γονιδίων
Issue date 2014-03-28
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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