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Identifier

000430178

Title

Design of engineered exosomes for a medical approach in a neurodegeneration mouse model

Alternative Title

Παραγωγή τροποποιημένων εξωσωμάτων ως θεραπευτικό όχημα σε νευροεκφυλιστικά σύνδρομα που σχετίζονται με τη συσσώρευση γενετικών βλαβών

Author

Νιώτης, Γεώργιος Θ.

Thesis advisor

Γαρίνης, Γεώργιος

Abstract

In parallel worn on lab, we have shown accumulation of ssDNA and dsDNA in different cell types (pancreatic and microglia cells) that lack ERCC1. Accumulation of cytoplasmic DNA has been shown in both cases to be connected with acute interferon-related innate immunity responses. In the case of microglia cytoplasmic DNA driven immune responses were shown to lead to a strong neurodegenerative phenotype. Exosomes are secreted vesicles and part of the normal intracellular communication. They have been implicated in numerous physiological and pathological states of cells and recently proposed as potential specific cargo/drug delivery system. We propose the production of engineered exosomes that will be targeted to specific cell types and will carry a nuclease able to degrade the cytoplasmic DNA thus reversing the acute inflammatory phenotype.

Language

English

Subject

DNA damage

Γενωμική αστάθεια

Issue date

2020-07-24

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses

Type of Work--Post-graduate theses

Views

301

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