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Home    Μελέτη της περιφερικής ανοσολογικής απάντησης σε ασθενείς με μεταστατικό καρκίνο του μαστού με τη χρήση της υγρής βιοψίας  

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Identifier 000443915
Title Μελέτη της περιφερικής ανοσολογικής απάντησης σε ασθενείς με μεταστατικό καρκίνο του μαστού με τη χρήση της υγρής βιοψίας
Alternative Title Investigation of the peripheral immune response in patients with metastatic breast cancer using liquid biopsy
Author Παπαδάκη,Ελένη
Thesis advisor Αγγελάκη, Σοφία
Reviewer Βεργίνης, Παναγιώτης
Κουτσόπουλος, Αναστάσιος
Abstract The role of the immune system in cancer immunoserveilance and immunoediting is vital. In particular, cancer cells exploit the mechanism of “immunoescape” to evade the immunoserveilance, which can lead to uncontrollable proliferation and finally to oncogenesis. While the immune response is a dynamic and constantly changeable biological process, its definition and characterization is limited by the conventional immunohistochemical analysis of the tumor. Therefore, “liquid biopsy” demonstrates great usefulness in this framework, as it involves the investigation of circulating tumor cells (CTCs) in the peripheral blood of cancer patients. It is a simple process with the choice of repetition in different time points, picturing the tumor profile in real time circumstances. Recent data claim the contribution of liquid biopsy in the investigation of the interactions between immune and cancer cells in real time, for the purpose of a better understanding regarding the immune response and the tumor immunoescape mechanisms. In the present study, molecules and pathways associated with the immune response will be investigated using the tool of liquid biopsy in breast cancer patients, of recurrent or de novo metastatic profile, about to receive their first line therapy. Specifically, the current study is focused on the pathway of Fas/FasL (FS-7- associated surface antigen/FS-7-associated surface antigen ligand) which is involved in the regulation of immune homoestasis, but also in tumor immunoescape, participating in both the innate and adaptive immunity. The expression of Fas and FasL molecules will be investigated simultaneously in CTCs and normal peripheral blood mononuclear cells (PBMCs) of patients' blood with the use of immunocytochemistry and microscopic observation. The present study is expected to contribute to the existing knowledge about the mechanisms of immunoescape in breast cancer, to highlight possible new goals of immunotherapy and to further explore the importance of liquid biopsy in this field of research.
Language Greek, English
Subject Circulating tumor cells
Immune escape
Ανοσοδιαφυγή
Κυκλοφορούντα καρκινικά κύτταρα
Issue date 2021-12-01
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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