|
Identifier |
000363242 |
Title |
Ο ρόλος των λιπαρών οξέων του υποδόριου λίπους και του γαστρικού βλενογόννου στους αμυντικούς μηχανισμούς του βλενογόννου στομάχου |
Alternative Title |
The role of fatty acids of the adipose tissue and the gastric mucosa in the defence of the gastric mucosa |
Author
|
Πάγκαλος, Βασίλειος Α
|
Thesis advisor
|
Κουρούμαλης, Ηλίας
|
Reviewer
|
Καφάτος, Αντώνης
Μουζάς, Ιωάννης
|
Abstract |
Background
Both in vitro and epidemiological studies indicate that dietary polyunsaturated fatty acids
may play a protective role against peptic ulcer in humans. Adipose tissue fatty acid
composition is thought to reflect dietary fatty acid intake. The aim of the present study is to
investigate adipose and gastric mucosa fatty acid levels in relation to gastric ulceration
status.
Methods
Fifty two adult outpatients undergoing upper gastrointestinal tract endoscopy participated in
the study. Adipose tissue samples were taken from the abdomen and buttock during the
endoscopy procedure and samples from gastric tissue were taken from a subsample of 30
subjects. The presence of Helicobacter pylori was determined using the CLO test. Capillary
gas chromatography was used for the extraction of adipose tissue and gastric mucosa lipids.
Results
The monounsaturated fatty acids (MUFAs) C18:1n‐12c, C16:1n‐5, C16:4n‐1 and the
polyunsaturated fatty acids (PUFAs) C16:3n‐4, C20:3n‐3, C20:4n‐6, C21:5n‐3 and C18:2n‐
9c,12t of the gastric mucosa were present in higher proportions in ulcer negative patients. In
addition, higher average levels of eicosapentaenoic acid (EPA) C20:5n‐3 and
docosahexaenoic acid (DHA) C22:6n‐3 were detected in abdominal and buttock samples in
CLO negative controls, compared to CLO positive controls.
Conclusions
Certain MUFAs and PUFAs of the gastric mucosa appear to be present in higher proportions
in ulcer negative patients. The higher average levels of EPA and DHA in abdominal and
buttock adipose tissue in CLO negative controls could be an indicator that dietary FAs inhibit
Helicobacter pylori growth.
|
Language |
Greek |
Subject |
Adipose tissue |
|
Fatty acids |
|
Gastric mucosa |
|
Helicobacter pylori |
|
Peptic Ulcer |
|
Γαστρικό έλκος |
|
Γαστροδωδεκαδακτυλικό έλκος |
|
Γστρικός βλενογόνννος |
|
Ελικοβακτηρίδιο του πυλωρού |
|
Λιπαρά οξέα |
|
Υποδόριο λίπος |
Issue date |
2009-07-24 |
Collection
|
School/Department--School of Medicine--Department of Medicine--Doctoral theses
|
|
Type of Work--Doctoral theses
|
Views |
281 |