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| Identifier |
000442919 |
| Title |
Ο ρόλος της κληρονομικής θρομβοφιλίας στους ασθενείς με χρόνια νεφρική νόσο – 5 υπό αιμοκάθαρση |
| Alternative Title |
Role of inherited thrombophilia risk factors in patients with chronic kidney diseases -5 receiving haemodialysis |
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Author
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Λιάπη, Δήμητρα
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Thesis advisor
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Αλεξανδράκης, Μιχάλης
Δαφνής, Ευγένιος
Στειακάκη, Ευτυχία
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Reviewer
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Παπαδάκη, Ελένη
Γουλιέλμος, Γεώργιος
Στυλιανού, Κωνσταντίνος
Καλπαδάκη, Χριστίνα
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| Abstract |
Background: The inherited thrombophilic mutations of the factor V gene (FVG1691A Leiden-FVL), prothrombin gene (FIIG20210A), and the methylenetetrahydrofolate reductase gene C677T(MTHFRC677T) are risk factors for thromboembolic events and are related to the pathogenesis of vascular diseases. Objectives: The main objective of this study was to explore the role of these factors in the pathogenesis of chronic kidney disease (CKD) and survival of patients with CKD-5 receiving haemodialysis. Methods: A cohort of 395 patients with CKD-5 on haemodialysis, from six dialysis units in Crete, Greece were recruited based on their medical records and were followed for five years. We collected data on CKD-5 aetiology, thrombophilic gene expression, vascular access thrombosis, time of death, and causes of death. Results: The mutated genes just as prevalent in patients with CKD-5 as they were in a control group with no renal disease (p>0.05). FVL heterozygosity was significantly more prevalent (11.4% vs 5.7%; p=0.036) in patients presented with CKD of unknown aetiologie, compared to CKD secondary to known aetiologies. There was not a significant relationship between the presence of vascular access thrombosis and the examined mutations (p>0.05). The survival of patients with CKD-5 receiving haemodialysis was not affected by the presence of any thrombophilic mutation. This held true for the whole cohort and for the cohort that included only lethal vascular events. Most patients with MTHFRC677T heterozygosity, and all patients with MTHFRC677T homozygosity, died from vascular events during the follow-up period. Conclusion: The FVL mutation may act as a risk factor for CKD. This study increases our understanding of molecular mechanisms in the pathogenesis of CKD of unknown aetiology. Τhe presence of thrombophilic mutations did not affect the overall survival of patients with CKD-5.
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| Language |
Greek |
| Issue date |
2021-12-01 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
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Type of Work--Doctoral theses
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| Views |
389 |
Ο ρόλος της κληρονομικής θρομβοφιλίας στους ασθενείς με χρόνια νεφρική νόσο – 5 υπό αιμοκάθαρση
